| Team | Player | POS | Status | Injury | Out For | Expected Return |
|---|---|---|---|---|---|---|
 Avalanche |  Radko Gudas | D | Sidelined | Torso Injury | Day-to-Day | 2025-04-23 |
 Devils |  Connor Murphy | D | Sidelined | Lower Body Injury | 1 Week | 2025-04-25 |
 Flyers |  Mikhail Sergachev | D | Injured Reserve | Bruised Left Arm Injury | 2 Weeks | 2025-04-29 |
 Hockey Club |  Robert Bortuzzo | D | Injured Reserve | Left Foot Injury | 3 Months | 2025-06-22 |
 Maple Leafs |  Brandt Clarke (R) | D | Injured Reserve | Strained Left Elbow Injury | 1 Week | 2025-04-27 |
| Maple Leafs |  Joel Edmundson | D | Injured Reserve | Right Leg Injury | 2 Weeks | 2025-04-30 |
| Maple Leafs |  Joseph Woll (R) | G | Sidelined | Bruised Left Foot Injury | 1 Week | 2025-04-24 |
 Panthers |  Marc-Edouard Vlasic | D | Injured Reserve | Left Knee Injury | 2 Weeks | 2025-05-03 |
 Sharks |  Tanner Jeannot | LW | Sidelined | Left Foot Injury | 1 Week | 2025-04-25 |
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